Which storage condition allows high risk compounded medications to maintain a BUD of 45 days?

High-risk compounded medications require stringent storage conditions to ensure their safety and efficacy. When stored in the freezer, these medications can maintain a beyond-use date (BUD) of up to 45 days, which helps to ensure their stability and prevent degradation. Freezing slows down the growth of microorganisms and chemical reactions that can diminish the integrity of the compounded medication, thus extending the time frame during which the medication can be safely used.

Room temperature storage typically has far shorter BUDs, as most compounds are more susceptible to degradation and contamination at these temperatures. Storing in a refrigerator also does not provide the necessary conditions for all high-risk medications, which may require even colder environments to ensure long-term stability. A biological safety cabinet provides an aseptic environment for the preparation of compounded medications, ensuring sterility during compounding, but does not influence the BUD once the medication is prepared and stored. Therefore, using a freezer is the most effective storage condition that aligns with the extended BUD of high-risk compounded medications.