Which abbreviation indicates a route of administration involving the spine?

The abbreviation indicating a route of administration involving the spine is "it," which stands for "intrathecal." This method involves delivering medications directly into the cerebrospinal fluid, which surrounds the spinal cord. This route is particularly useful for certain medications, such as those used for pain management or chemotherapy, as it allows for direct action in the central nervous system.

In contrast, the other choices refer to different routes of administration: "im" refers to intramuscular, which involves injecting medication into a muscle; "bu" refers to buccal, indicating that the medication is placed between the gum and the inner lining of the cheek for absorption; and "od" generally denotes an ophthalmic dose, referring to medication administered to the eye. Understanding these distinctions is crucial for pharmacy technicians, as proper administration routes significantly affect medication efficacy and patient safety.