What risk is associated with NSAIDs that must be communicated through a medication guide?

The risk associated with NSAIDs (non-steroidal anti-inflammatory drugs) that must be communicated through a medication guide is the risk of gastrointestinal bleeding. This is a significant concern because NSAIDs can inhibit the production of prostaglandins, which are protective factors in the gastrointestinal (GI) mucosa. When these protective factors are diminished, it increases the likelihood of developing ulcers and gastrointestinal bleeding, particularly with long-term use or in individuals with pre-existing risk factors.

Health professionals are required to inform patients about this risk, allowing them to make informed decisions regarding their pain management options and to be vigilant about any symptoms that might indicate a serious problem (such as stomach pain, black or bloody stools). Understanding this risk is critical for safe use of NSAIDs, as it addresses a potentially life-threatening complication that can arise from these commonly used medications.