What is the potential risk associated with metoclopramide that necessitates a medication guide?

Metoclopramide, a medication primarily used for gastrointestinal issues like nausea and gastroparesis, carries a significant risk of tardive dyskinesia, which is an involuntary movement disorder. This condition can develop after prolonged use of metoclopramide, especially in older adults or those on high doses. The risk is substantial enough that a medication guide is required to inform patients about this potential side effect, ensuring they understand the importance of monitoring for symptoms.

Tardive dyskinesia can manifest as repetitive, involuntary movements, particularly of the face and extremities, and may persist even after discontinuation of the medication. The guidance aims to promote awareness and preventive measures among both patients and healthcare providers, emphasizing the importance of using metoclopramide for the shortest duration necessary at the appropriate dosage.

While allergic reactions, sedation, and nausea are important considerations when prescribing medications, they do not specifically warrant the same level of caution or necessitate a medication guide as the risk associated with tardive dyskinesia does.