What is meant by Category D pregnancy risk?

The correct interpretation of Category D pregnancy risk indicates that there is established evidence of risk to the fetus based on human data. This classification suggests that while the use of certain medications may pose a risk, they may still be necessary in some circumstances. Healthcare providers are advised to weigh the potential benefits of treatment against the risks when prescribing drugs in this category. This highlights the importance of clinical judgment in managing conditions that may require such medications during pregnancy.

In contrast to this category, other classifications imply no risk or lack of sufficient data to establish risk, which does not apply to Category D. Furthermore, unlike Category D, Category A indicates no risk to the fetus, while Category C suggests that animal studies may indicate adverse effects, but there is insufficient human data. Therefore, Category D serves as a clear guideline for careful consideration in the context of treating pregnant women when risks are acknowledged but may be justifiable.